C5 Antibody (Monoclonal)

A murine monoclonal antibody to an epitope on C5.

Product Specifications

Citations 9
Clonality

Monoclonal
Immunogen Purified human protein.
Applications See citations and technical data sheet for application info.
Concentration 1.0-1.2 mg/mL
Conjugate Unconjugated
Cross Reactivity

Human, Baboon
Technical Documents

Ordering Information

For Research Use Only in the United States. Not for use in diagnostic procedures.
Catalog Number A217
Catalog Number (CE) N/A
Size 100 µl
Price (USD) $365.00
Price (EURO) 330,00 €
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Contact us

US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

A murine monoclonal antibody to an epitope on C5.
Size 100 µl
Concentration

1.0-1.2 mg/mL

Applications See citations and technical data sheet for application info.
Form Liquid. Borate Buffered Saline (pH 8.4 ± 0.2), with ≤ 0.1% Sodium Azide.
Clonality Monoclonal
Immunogen Purified human protein.
Conjugate Unconjugated
Cross Reactivity Human, Baboon
Isotype IgG1k
Purity ≥ 95% by SDS PAGE
Source

Mouse
Specificity This monoclonal antibody was raised against purified human C5. It is specific for an antigen expressed on the C5 but not on MAC Complex. This antibody inhibits the lysis of EA and will not bind to MAC bound to a membrane.
Storage

Short term (30 days) 4˚C. Long term at or below –20˚C.
Background

Complement protein, C5 is unique to the Terminal Complement Pathway. The C5 protein is composed of two subunits (Alpha – 115,000 kD and Beta – 75,000 kD) and is present in serum at a concentration of approximately 70 mg/L. Under normal conditions, activation of either the Classical, Lectin or Alternative Complement Pathways generates the C5 convertase which is capable of cleaving C5 into two fragments – C5a (a potent anaphylatoxin) and C5b. Together with other proteins of the Terminal Pathway, C5b forms the Membrane Attack Complex (MAC) or Terminal Complement Complex (TCC) at the surface of a target cell; resulting in cell lysis.

Certificate of Analysis

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