C1-INH Antibody (Polyclonal)

A goat antiserum raised against human C1 Inhibitor protein.


Product Specifications

Citations 6
Clonality

Polyclonal

Immunogen Highly purified human C1-inhibitor protein
Applications See citations and technical data sheet for application info.
Concentration > 40 mg/mL
Conjugate Unconjugated
Cross Reactivity

Human, Baboon, Dog, Rabbit

Ordering Information

For Research Use Only in the United States. Not for use in diagnostic procedures.
Catalog Number A300
Catalog Number (CE) N/A
Size 2.0 mL
Price (USD) $195.00
Price (EURO) 170,00 €

Contact us

US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

A goat antiserum raised against human C1 Inhibitor protein.

Size 2.0 mL
Concentration

> 40 mg/mL

Applications See citations and technical data sheet for application info.
Form Liquid. Whole Antiserum. ≤ 0.1% Sodium Azide
Clonality Polyclonal
Immunogen Highly purified human C1-inhibitor protein
Conjugate Unconjugated
Cross Reactivity Human, Baboon, Dog, Rabbit
Isotype Goat IgG
Purity N/A
Source

Goat

Specificity The C1-inhibitor polyclonal antisera was tested against normal human plasma by double immunodiffusion, one-dimensional immunoelectrophoresis, quantitative radial immunodiffusion, and quantitative rocket immunoelectrophoresis. The antiserum was determined to be monospecific for C1-inhibitor at varying concentrations.
Storage

Short term (30 days) 4˚C. Long term at or below –20˚C.

Background

C1-inhibitor is a multi-specific protease inhibitor present in human plasma and serum. Normal human serum shows a concentration of approximately 200 µg/mL. C1-inhibitor is a glycoprotein with an approximate molecular weight of 110 kD. This protein contains many glycosylation sites, so the molecular weight varies depending on the quantity of sites that are glycosylated. Among the proteins regulated by C1-inhibitor are C1s and C1r of the complement complex. Regulation and inactivation of C1s and C1r effectively limits the consumption of complement components C2 and C4. Genetic deficiencies of C1-inhibitor are of two types: functional deficiencies (protein is present but not functional) and antigen deficiencies (protein is not present, or more commonly, present at a low level). Either of these may lead to life threatening hereditary angioedema (HAE).