sC5b-9 Antibody (Monoclonal - neoantigen)
A murine monoclonal antibody to a neoantigen on the terminal complement complex.
Product Specifications
| Citations | 27 |
|---|---|
| Clonality |
Monoclonal |
| Immunogen | Purified human protein. |
| Applications | See citations and technical data sheet for application info. |
| Concentration | 1.0-1.2 mg/mL |
| Conjugate | Unconjugated |
| Cross Reactivity |
Human, Baboon, Cynomologus macaque, Rhesus macaque. |
Ordering Information
| Catalog Number | A239 |
|---|---|
| Catalog Number (CE) | N/A |
| Size | 100 µl |
| Price (USD) | $375.00 |
| Price (EURO) | 340,00 € |
Contact us
| US Phone | +1 (858) 552 1100 |
|---|---|
| EU Phone | +353 (91) 412 474 |
| US Email | contact-us@quidelortho.com |
| EU Email | contact-emea@quidelortho.com |
- Specifications
- Citations
- Certificate of Analysis
Specifications
| Description |
A murine monoclonal antibody to a neoantigen on the terminal complement complex. |
|---|---|
| Size | 100 µl |
| Concentration |
1.0-1.2 mg/mL |
| Applications | See citations and technical data sheet for application info. |
| Form | Liquid. Borate Buffered Saline (pH 8.4 ± 0.2), with ≤ 0.1% Sodium Azide. |
| Clonality | Monoclonal |
| Immunogen | Purified human protein. |
| Conjugate | Unconjugated |
| Cross Reactivity | Human, Baboon, Cynomologus macaque, Rhesus macaque. |
| Isotype | IgG2bk |
| Purity | ≥ 95% by SDS PAGE |
| Source |
Mouse |
| Specificity | This monoclonal antibody was raised against purified human C9. This antibody has been shown to bind to a neoantigen expressed on SC5b-9, TCC, MAC, poly- C9 and on denatured immobilized C9. |
| Storage |
Short term (30 days) 4˚C. Long term at or below –20˚C. |
| Background |
The Terminal Complement Complex (TCC, SC5b-9) is generated by the assembly of C5 through C9 as a consequence of activation of the complement system by either the classical, lectin or alternative pathway. The membrane attack complex (MAC), a form of TCC, is a stable complex that mediates the irreversible target cell membrane damage associated with complement activation. Complexes formed in the absence of a target membrane bind to naturally occurring regulatory serum proteins, e.g. the S protein, at the C5b-7 stage of assembly forming soluble, non-lytic TCC. |
