Factor B Antibody (Polyclonal)

A goat antiserum raised against human Factor B.


Product Specifications

Citations 18
Clonality

Polyclonal

Immunogen Highly purified human Factor B protein
Applications See citations and technical data sheet for application info.
Concentration > 40 mg/mL
Conjugate Unconjugated
Cross Reactivity

Human, Baboon, Horse, Dog, Cat, Rabbit, Hamster, Mouse, Rat, Guinea Pig, Swine

Ordering Information

For Research Use Only in the United States. Not for use in diagnostic procedures.
Catalog Number A311
Catalog Number (CE) N/A
Size 2.0 mL
Price (USD) $200.00
Price (EURO) 175,00 €

Contact us

US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

A goat antiserum raised against human Factor B.

Size 2.0 mL
Concentration

> 40 mg/mL

Applications See citations and technical data sheet for application info.
Form Liquid. Whole Antiserum. ≤ 0.1% Sodium Azide
Clonality Polyclonal
Immunogen Highly purified human Factor B protein
Conjugate Unconjugated
Cross Reactivity Human, Baboon, Horse, Dog, Cat, Rabbit, Hamster, Mouse, Rat, Guinea Pig, Swine
Isotype Goat IgG
Purity N/A
Source

Goat

Specificity The Anti-Human Factor B polyclonal antisera was tested by double-immunodiffusion, one-dimensional immunoelectrophoresis, quantitative radial immunodiffusion, and quantitative rocket immunoelectrophoresis. The antisera was determined to be monospecific for the Factor B protein.
Storage

Short term (30 days) 4˚C. Long term at or below –20˚C.

Background

Primarily synthesized in the liver, Factor B is a plasma protein that is unique to the alternative pathway of the Complement system. The average concentration of Factor B in human serum/plasma is approximately 200 µg/mL. Factor B present in the circulatory system is a single-chain polypeptide with a molecular weight of 93 KD. Factor B will bind to the C3b component of the complement system in the presence of Mg++ to form the C3bB complex. This complex can be activated through cleavage of the Factor B portion by Factor D, which releases the Ba fragment of Factor B while the Bb fragment of Factor B remains bound to C3b. The C3bBb complex acts as a C3 and C5 convertase due to the serine protease activity of the Bb fragment. Presence of the split products (Ba and Bb fragments of Factor B) indicate that the alternative complement pathway has been activated. Factor B, like C2 and C4 is characterized as a Class III major histocompatibility complex (MHC) antigen. The structural gene coding for this protein is located within the MHC on chromosome 6 in man, and chromosome 17 in mice.