MicroVue™ Complement Multiplex

ELISA based chemiluminescent multiplex for complement sytsem analytes.

ELISA

Cynomolgus Monkey:  CSF, Serum, Vitreous
Humor Rhesus Monkey:  Serum
Contact Technical Services for additional information regarding cross-reactivity details

The Complement System consists of more than 40 fluid and membrane-bound proteins and protein fragments organized into three primary pathways: Classical, Alternative, and Lectin . By a series of specific activation steps via either the classical, alternative, or the lectin pathway, the complement proteins mediate a set of activities ranging from the initiation of inflammation, clearance of immune complexes, disruption of cell membranes, and regulation of the immune response. Deficiencies in the complement cascade can predispose individuals to infection through ineffective opsonization or defects in the ability to lyse invading pathogens. Besides its essential role in maintaining health, the importance of the complement system in medicine lies in the fact that many acute and chronic diseases are associated with abnormalities in its function. Accordingly, quantitative analysis of different complement proteins and their activation by-products are of great practical importance in medical research.  There are numerous immunological methods for complement testing, including individual protein ELISA-based kits measuring complement cleavage products as markers of complement activation. However, the ability to measure multiple complement proteins in an individual sample constitutes a major step forward in research based tools.