C1q Antibody (Polyclonal)

A goat antiserum raised against human C1q protein


Product Specifications

Citations 14
Clonality

Polyclonal

Immunogen Highly purified human human C1q protein
Applications See citations and technical data sheet for application info.
Concentration > 40 mg/mL
Conjugate Unconjugated
Cross Reactivity

Human, Baboon, Horse, Dog, Cat, Rabbit, Hamster, Mouse, Rat, Guinea Pig

Ordering Information

For Research Use Only in the United States. Not for use in diagnostic procedures.
Catalog Number A301
Catalog Number (CE) N/A
Size 2.0 mL
Price (USD) $240.00
Price (EURO) 210,00 €

Contact us

US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

A goat antiserum raised against human C1q protein

Size 2.0 mL
Concentration

> 40 mg/mL

Applications See citations and technical data sheet for application info.
Form Liquid. Whole Antiserum. ≤ 0.1% Sodium Azide
Clonality Polyclonal
Immunogen Highly purified human human C1q protein
Conjugate Unconjugated
Cross Reactivity Human, Baboon, Horse, Dog, Cat, Rabbit, Hamster, Mouse, Rat, Guinea Pig
Isotype Goat IgG
Purity N/A
Source

Goat

Specificity The Anti-human C1q was tested against normal human plasma by double immunodiffusion, one-dimensional immunoelectrophoresis, two-dimensional immunoelectrophoresis, and quantitative rocket immunoelectrophoresis. The antiserum was determined to be monospecific for C1q at varying concentrations.
Storage

Short term (30 days) 4˚C. Long term at or below –20˚C.

Background

The C1q molecule is a large protein with a molecular weight of 410 kD. This hexamer is composed of three unique protein subunits (A, B, and C) with molecular weights of 29, 26, and 22 kD respectively, and is present in normal human serum at an approximate concentration of 70 µg/mL. The assembled C1q molecule contains a central core or stalk, six collagen-like domains and six globular protein heads, resulting in a the appearance of a “bouquet of tulips.” The globular or terminal regions are responsible for binding the Fc portion of immunoglobulin (IgM, and IgG). C1q is one of three subcomponents that together make the first component of the classical complement pathway, C1. C1q complexes with two C1s and two C1r components, and together, they form the C1 complex. Initiation of the classical complement pathway occurs when C1q binds with IgM or IgG containing antigen-antibody complexes.