Factor I Protein

Purified human Factor I protein

Product Specifications

Citations 2
Description

Purified human Factor I protein
Storage Store at -70°C or below. Avoid freeze/thaw.
Form

Frozen liquid. 10 mM Sodium phosphate, 145 mM NaCl, pH 7.2. No preservative, 0.22 µm filtered.
Concentration 1.0 mg/mL (refer to CoA for lot specific concentration)
Applications

See citations and technical data sheet for application info.
Technical Documents

Ordering Information

For Research Use Only. Not for use in diagnostic procedures.
Catalog Number A411
Catalog Number (CE) N/A
Size 250 µL
Price (USD) $725.00
Price (EURO) 475,00 €
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Specifications

Description

Purified human Factor I protein
Size 250 µL
Storage

Store at -70°C or below. Avoid freeze/thaw.

Form Frozen liquid. 10 mM Sodium phosphate, 145 mM NaCl, pH 7.2. No preservative, 0.22 µm filtered.
Concentration 1.0 mg/mL (refer to CoA for lot specific concentration)
Applications See citations and technical data sheet for application info.
Purity >95% by SDS-PAGE
Source

Normal human serum
Activity Cleaves C3b with factor H as a cofactor
Molecular Weight 88,000 Da (2 chains)
Background

Purified human complement component Factor I. Factor I is a fluid phase complement regulatory enzyme. It consists of two peptide chains with molecular weights of 50 kD and 38 kD, respectively. Factor I is present in plasma at 35 mg/L. With Factor H, CR1 or C4 Binding Protein acting as a cofactor, Factor I cleaves the C3b subunit of the alternative and classical pathway convertases, thereby inactivating them.

Certificate of Analysis

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