Cobra Venom Factor - Recombinant
Uniform pool of recombinant Cobra Venom Factor (CVF), a non-toxic complement activating reagent.
Product Specifications
| Citations | 0 |
|---|---|
| Description |
Uniform pool of recombinant Cobra Venom Factor (CVF), a non-toxic complement activating reagent. |
| Storage | Store at -70°C or below. Minimize freeze/thaw cycles. |
| Form |
Frozen liquid (Phosphate Buffered Saline, pH 7.2 ± 0.2) |
| Concentration | 100 μg/mL |
| Applications |
See citations and technical data sheet for application info. |
Ordering Information
| Catalog Number | A601 |
|---|---|
| Catalog Number (CE) | N/A |
| Size | 0.5 mL |
| Price (USD) | $535.00 |
| Price (EURO) | 535,00 € |
Contact us
| US Phone | +1 (858) 552 1100 |
|---|---|
| EU Phone | +353 (91) 412 474 |
| US Email | contact-us@quidelortho.com |
| EU Email | contact-emea@quidelortho.com |
- Specifications
- Citations
- Certificate of Analysis
Specifications
| Description |
Uniform pool of recombinant Cobra Venom Factor (CVF), a non-toxic complement activating reagent. |
|---|---|
| Size | 0.5 mL |
| Storage |
Store at -70°C or below. Minimize freeze/thaw cycles. |
| Form | Frozen liquid (Phosphate Buffered Saline, pH 7.2 ± 0.2) |
| Concentration | 100 μg/mL |
| Applications | See citations and technical data sheet for application info. |
| Purity | ≥ 95% by SDS page |
| Source |
Refer to certificate of analysis |
| Activity | ≥ 350 units |
| Molecular Weight | N/A |
| Background |
Cobra Venom Factor (CVF), sometimes referred to as C3b(Cobra), is the non-toxic, complement activating component of cobra venom. Like naturally occurring C3b, CVF forms a complex with complement components Factor B and Factor D. This CVFBbD convertase is capable of activating C3 in a wide variety of species via the alternative complement pathway. Unlike the naturally occurring convertase (C3bBbD), the C3b(Cobra)BbD convertase is Factor H resistant and is therefore not inactivated by Factor I or CR1. Given appropriate incubation time, CVF will convert nearly 100% of the C3 to C3 end products. Unlike CVF purified from the Naja naja haje species, CVF from Naja naja kaouthia activates the terminal pathway directly by forming a C5 convertase. This depletes C5 in a manner analogous to that described above for C3. Levels of iC3b, C3a, SC5b-9, C5a and the Factor B cleavage product Bb are all extremely high in CVF treated sera. |
Citations
| Title | Year | Applications | Sample Species | Sample | Sample Details |
|---|
Certificate of Analysis
