Clusterin Antibody (Monoclonal)

A murine monoclonal antibody to Clusterin (Apo J, SP 40,40).

Product Specifications

Citations 5
Clonality

Monoclonal
Immunogen Purified human protein.
Applications See citations and technical data sheet for application info.
Concentration 1.0-1.2 mg/mL
Conjugate Unconjugated
Cross Reactivity

Human
Technical Documents

Ordering Information

For Research Use Only in the United States. Not for use in diagnostic procedures.
Catalog Number A241
Catalog Number (CE) N/A
Size 100 µl
Price (USD) $365.00
Price (EURO) 330,00 €
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US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

A murine monoclonal antibody to Clusterin (Apo J, SP 40,40).
Size 100 µl
Concentration

1.0-1.2 mg/mL

Applications See citations and technical data sheet for application info.
Form Liquid. Borate Buffered Saline (pH 8.4 ± 0.2), with ≤ 0.1% Sodium Azide.
Clonality Monoclonal
Immunogen Purified human protein.
Conjugate Unconjugated
Cross Reactivity Human
Isotype IgG1k
Purity ≥ 95% by SDS PAGE
Source

Mouse
Specificity This monoclonal antibody was raised against purified human Clusterin. It has been designated clone G7.
Storage

Short term (30 days) 4˚C. Long term at or below –20˚C.
Background

Clusterin, also called complement lysis inhibitor, SP-40, 40, Apolipoprotein J (Apo J), is a 449 amino acid protein with a molecular weight of 75-80 kD. Clusterin is a heterodimer consisting of alpha and beta chains of approximately equal size (35-40 kD); the chains being linked by a unique five-disulfide bond motif. Serum concentration of clusterin is 50-100 µg/mL and is present in most organs, with the highest level of mRNA expression in brain, adrenal medulla, ovary, testis and liver. Within the complement system, clusterin modulates the function of the Terminal Complement cascade to prevent lysis by the Membrane Attack Complex (C5b-9). Clusterin is found in non-lytic C5b-9 complexes, which also contain Vitronectin. Clusterin binds to C5b-7, C5b-8 or C5b-9 during assembly of the amphiphillic complex.

Certificate of Analysis

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