SC5b-9 Protein

Purified human SC5b-9 protein

Store at -70°C or below. Avoid freeze/thaw.

Frozen liquid. 10 mM sodium phosphate, 145 mM NaCl, pH 7.3. No preservative, 0.22 µm filtered.

Vitronectin (S Protein) binds to membrane attack complexes that fail to insert into membranes. The result is a soluble complex of S Protein and C5b-9 and this has been named SC5b-9. Activation of complement in the absence of bilipid layer membranes results in most of the activated C5 forming SC5b-9 complexes. This can occur with activating particles such as immune complexes, yeast and bacterial cell walls. The SC5b-9 complexes can have more than one C9 (usually three) and more than one S Protein (usually three) per complex.