MicroVue™ CICP EIA

The MicroVue CICP assay measures type I C-terminal collagen propeptide (CICP) in serum.

Product Specifications

Citations17
Specimen

Serum 25 μL

LLOQ1 ng/mL
ULOQ80 ng/mL
Assay Time4 hours
Cross Reactivity

Cynomolgous monkey, Rabbit, Rhesus monkey

Technical Documents

Ordering Information

For Research Use Only in the United States. Not for use in diagnostic procedures.
Catalog Number8005
Catalog Number (CE)8003
Size96 wells/test
Price (USD)$835.00
Price (EURO)740,00 €
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US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

The MicroVue CICP assay measures type I C-terminal collagen propeptide (CICP) in serum.

Size96 wells/test
Form

96 well plate with 12 eight-well strips in a resealable foil pouch

SpecimenSerum 25 μL
Limit of Detection (LOD)0.2 ng/mL
Lower Limit of Quantitation (LLOQ)1 ng/mL
Upper Limit of Quantitation (ULOQ)80 ng/mL
Intra Assay5.5–6.8%
Inter Assay5–7%
Standards6
Controls2
Sample Values

Adult: 69–103 ng/mL, Children: 110–966 ng/mL

Assay Time4 hours
Cross Reactivity

Cynomolgous monkey, Rabbit, Rhesus monkey

Storage

Store unopened kit between 2°C to 8°C. Refer to manual for storing individual components

Background

Collagen, the triple-helical molecule which forms the fibrous framework of all connective tissues, is synthesized as procollagen, a larger precursor molecule. Procollagen consists of mature collagen with extension peptides at both the amino and carboxy termini. These extension peptides, or propeptides, are cleaved from the collagen molecule by specific proteases prior to incorporation of collagen into a growing collagen fibril. The release of these peptides into the circulation provides a stoichiometric representation of the production of collagen.

Citations

TitleYearApplicationsSample SpeciesSampleSample Details

Re-Differentiation Capacity of Human Chondrocytes in Vitro Following Electrical Stimulation with Capacitively Coupled Fields.

2019ELISAHuman

Chondrocytes

N/A

Bone turnover biomarkers identify unique prognostic risk groups in men with castration resistant prostate cancer and skeletal metastases: Results from SWOG S0421.

2018ELISAHuman

Serum

N/A

New insights into tenocyte-immune cell interplay in an in vitro model of inflammation.

2017ELISAHuman

Peripheral blood mononuclear cells

N/A

Circulating LOXL 2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4 + T Lymphocyte Depletion in Treated HIV Infection.

2017ELISAHuman

Plasma

HIV

Negative Effects of Total Gastrectomy on Bone Tissue Metabolism and Volumetric Bone Mineral Density (vBMD) of Lumbar Spine in 1-Year Study in Men.

2016ELISAHuman

Serum

N/A

Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis.

2016ELISARabbit

Plasma

N/A

Infection of Human Liver Myofibroblasts by Hepatitis C Virus: A Direct Mechanism of Liver Fibrosis in Hepatitis C.

2015ELISAHuman

Liver Myofibroblasts

HCV Infected

Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo.

2015ELISAHuman

Skin Tissue

N/A

Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy.

2015ELISARhesus Monkey

Serum

N/A

Calcipotriol counteracts betamethasone-induced decrease in extracellular matrix components related to skin atrophy.

2014ELISAHuman

Fibroblasts

N/A

Serum biomarkers of bone metabolism in castration-resistant prostate cancer patients with skeletal metastases: results from SWOG 0421.

2014ELISAHuman

Serum

N/A

Circulating matrix metalloproteinases in adolescents with hypertrophic cardiomyopathy and ventricular arrhythmia.

2012ELISAHuman

Plasma

N/A

Changes in serum collagen markers, IGF-I, and knee joint laxity across the menstrual cycle.

2012ELISAHuman

Serum

N/A

Migration Capacity and Viability of Human Primary Osteoblasts in Synthetic Three-dimensional Bone Scaffolds Made of Tricalciumphosphate.

2011ELISAHuman

Osteoblasts

N/A

Modulation of fibroblast inflammatory response by surface modification of a perfluorinated ionomer.

2011ELISAN/A

Nafion

N/A

Use of small interfering ribonucleic acids to inhibit the adipogenic effect of alcohol on human bone marrow-derived mesenchymal cells.

2010ELISAHuman

Mesenchymal Cells

N/A

The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein.

2006ELISAHuman

Osteoblasts

N/A

Certificate of Analysis

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