Klotho Antibody (KL2)

A mouse monoclonal antibody to human Klotho.

100 µg

Purified human klotho protein.

IgG1λ

≥ 95% by SDS PAGE

The specificity of the monoclonal antibody was established via epitope mapping and a series of immunoassays. The antibody binds the KL2 domain of the Klotho protein.

Short term (30 days) 4˚C. Long term at or below –20˚C.

Klotho is a type-I transmembrane protein that is associated with many functions. A novel ß-glucuronidase, Klotho has been associated with phosphate regulation, organ protection, and aging, among others. Though a single gene, it has three major isoforms: the transmembrane form, a shed soluble form, and a truncated soluble form. The extracellular portion of the protein consists of two glycosyl hydrolase domains referred to as KL1 and KL2. Upon cleavage at the base of the extracellular domain the protein becomes the shed soluble form and is an active form that functions as a hormone. Importantly, Klotho is a receptor and a co-receptor of the phosphate regulation protein FGF-23. While Klotho/FGF-23 homeostasis has primarily been focused on phosphate and vitamin D regulation, continuing research is associating Klotho and FGF-23 with functionality that impacts the heart, bones, blood vessels, and parathyroid gland.