C7 Antibody (Monoclonal) , Biotinylated

A biotin conjugated murine monoclonal antibody to an epitope on C7 protein.

250 µL

Purified human protein.

IgG1k

≥ 95% by SDS PAGE

This monoclonal antibody was raised against purified human C7. It is specific for an Antigen expressed on native C7 but not expressed in MAC. It will inhibit the lysis of EA and will not detect membrane bound MAC.

Short term (30 days) 4˚C. Long term at or below –20˚C.

Complement component C7 is a single-chain glycoprotein with a molecular weight of 95 kD. C7 protein is present in human plasma at an approximate concentration of 55 μg/ml. Upon activation of the lectin, classical or alternative pathways, C7 becomes integrated into the terminal complement complex. The Terminal Complement Complex (TCC) is a general term for both membrane-bound C5b-9, or Membrane Attack Complex (MAC), and fluid phase SC5b-9. TCC is an excellent marker for quantifying the extent of terminal pathway activation in vivo or in vitro. TCC can be deposited on the surface of transformed cells, biomaterials, as well as, a variety of other materials.