C4a Antibody (Polyclonal)

A rabbit antiserum raised against human complement C4a protein.

1.0 mL

Highly purified human C4a

Rabbit IgG

N/A

The Anti-Human C4a polyclonal antisera was tested by immunodiffusion methods and determinded to be monospecific for the C4a protein.

Short term (30 days) 4˚C. Long term at or below –20˚C.

Under normal conditions, activation of the classical or lectin complement pathways results in the cleavage of the complement protein, C4 into C4a and C4b by the protease C1s. C4a is rapidly cleaved to its more stable, less active form C4a-des Arg by endogenous serum carboxypeptidase N enzyme. Thus, detection of C4a-des Arg provides a reliable evaluation of classical or lectin complement pathway activation.