C3c Protein
Purified human C3c protein
Product Specifications
| Citations | 1 |
|---|---|
| Description | Purified human C3c protein |
| Storage | Store at -70°C or below. Avoid freeze/thaw. |
| Form | Frozen liquid. 10 mM Sodium phosphate, 145 mM NaCl, pH 7.2. No preservative, 0.22 µm filtered. |
| Concentration | 1.0 mg/mL (refer to CoA for lot specific concentration) |
| Applications | See citations and technical data sheet for application info. |
Ordering Information
| Catalog Number | A417 |
|---|---|
| Catalog Number (CE) | N/A |
| Size | 250 µL |
| Price (USD) | $390.00 |
| Price (EURO) | 315,00 € |
Contact us
| US Phone | +1 (858) 552 1100 |
|---|---|
| EU Phone | +353 (91) 412 474 |
| US Email | contact-us@quidelortho.com |
| EU Email | contact-emea@quidelortho.com |
- Specifications
- Citations
- Certificate of Analysis
Specifications
| Description | Purified human C3c protein |
|---|---|
| Size | 250 µL |
| Storage | Store at -70°C or below. Avoid freeze/thaw. |
| Form | Frozen liquid. 10 mM Sodium phosphate, 145 mM NaCl, pH 7.2. No preservative, 0.22 µm filtered. |
| Concentration | 1.0 mg/mL (refer to CoA for lot specific concentration) |
| Applications | See citations and technical data sheet for application info. |
| Purity | >90% by SDS-PAGE |
| Source | Normal human serum |
| Activity | No activity |
| Molecular Weight | 139,000 Da (3 chains) |
| Background | C3c is derived from iC3b (inactivated C3b) by proteolytic cleavage. iC3b is created by cleavage of C3b by factor I in the presence of factor H, CR1 or MCP. C3c can be produced by an additional cleavage by factor I if the iC3b is bound to CR1. Factor H cannot serve as a cofactor for this cleavage. C3c can also be produced by the action of trypsin-like proteases on iC3b. If the C3b precursor was attached to a surface, then the iC3b will remain attached to that surface and when iC3b is cleaved the C3c is released into the surrounding solution while the C3dg/C3d fragment remains on that surface. The breakdown of fluid phase C3b is similar, but in this case both C3c and C3dg/C3d are soluble fragments. |
Citations
| Title | Year | Applications | Sample Species | Sample | Sample Details |
|---|---|---|---|---|---|
Complement-Mediated Selective Tumor Cell Lysis Enabled by Bi-Functional RNA Aptamers. | 2021 | Binding Assay | Cell Culture | MDA-MB-231 Cells | N/A |
Certificate of Analysis
