MicroVue™ CICP EIA

The MicroVue CICP assay measures type I C-terminal collagen propeptide (CICP) in serum.


Product Specifications

Citations 17
Specimen

Serum 25 μL

LLOQ 1 ng/mL
ULOQ 80 ng/mL
Assay Time 4 hours
Cross Reactivity

Cynomolgous monkey, Rabbit, Rhesus monkey

Ordering Information

For Research Use Only in the United States. Not for use in diagnostic procedures.
Catalog Number 8005
Catalog Number (CE) 8003
Size 96 wells/test
Price (USD) $835.00
Price (EURO) 740,00 €

Contact us

US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

The MicroVue CICP assay measures type I C-terminal collagen propeptide (CICP) in serum.

Size 96 wells/test
Form

96 well plate with 12 eight-well strips in a resealable foil pouch

Specimen Serum 25 μL
Limit of Detection (LOD) 0.2 ng/mL
Lower Limit of Quantitation (LLOQ) 1 ng/mL
Upper Limit of Quantitation (ULOQ) 80 ng/mL
Intra Assay 5.5–6.8%
Inter Assay 5–7%
Standards 6
Controls 2
Sample Values

Adult: 69–103 ng/mL, Children: 110–966 ng/mL

Assay Time 4 hours
Cross Reactivity

Cynomolgous monkey, Rabbit, Rhesus monkey

Storage

Store unopened kit between 2°C to 8°C. Refer to manual for storing individual components

Background

Collagen, the triple-helical molecule which forms the fibrous framework of all connective tissues, is synthesized as procollagen, a larger precursor molecule. Procollagen consists of mature collagen with extension peptides at both the amino and carboxy termini. These extension peptides, or propeptides, are cleaved from the collagen molecule by specific proteases prior to incorporation of collagen into a growing collagen fibril. The release of these peptides into the circulation provides a stoichiometric representation of the production of collagen.

Citations

Title Year Applications Sample Species Sample Sample Details

The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein.

2006

ELISA

Human

Osteoblasts

Use of small interfering ribonucleic acids to inhibit the adipogenic effect of alcohol on human bone marrow-derived mesenchymal cells.

2010

ELISA

Human

Mesenchymal Cells

Changes in serum collagen markers, IGF-I, and knee joint laxity across the menstrual cycle.

2012

ELISA

Human

Serum

Circulating matrix metalloproteinases in adolescents with hypertrophic cardiomyopathy and ventricular arrhythmia.

2012

ELISA

Human

Plasma

Serum biomarkers of bone metabolism in castration-resistant prostate cancer patients with skeletal metastases: results from SWOG 0421.

2014

ELISA

Human

Serum

Calcipotriol counteracts betamethasone-induced decrease in extracellular matrix components related to skin atrophy.

2014

ELISA

Human

Fibroblasts

Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo.

2015

ELISA

Human

Skin Tissue

Infection of Human Liver Myofibroblasts by Hepatitis C Virus: A Direct Mechanism of Liver Fibrosis in Hepatitis C.

2015

ELISA

Human

Liver Myofibroblasts

HCV Infected

Negative Effects of Total Gastrectomy on Bone Tissue Metabolism and Volumetric Bone Mineral Density (vBMD) of Lumbar Spine in 1-Year Study in Men.

2016

ELISA

Human

Serum

Circulating LOXL 2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4 + T Lymphocyte Depletion in Treated HIV Infection.

2017

ELISA

Human

Plasma

HIV

Migration Capacity and Viability of Human Primary Osteoblasts in Synthetic Three-dimensional Bone Scaffolds Made of Tricalciumphosphate.

2011

ELISA

Human

Osteoblasts

New insights into tenocyte-immune cell interplay in an in vitro model of inflammation.

2017

ELISA

Human

Peripheral blood mononuclear cells

Bone turnover biomarkers identify unique prognostic risk groups in men with castration resistant prostate cancer and skeletal metastases: Results from SWOG S0421.

2018

ELISA

Human

Serum

Re-Differentiation Capacity of Human Chondrocytes in Vitro Following Electrical Stimulation with Capacitively Coupled Fields.

2019

ELISA

Human

Chondrocytes

Modulation of fibroblast inflammatory response by surface modification of a perfluorinated ionomer.

2011

ELISA

N/A

Nafion

Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis.

2016

ELISA

Rabbit

Plasma

Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy.

2015

ELISA

Rhesus Monkey

Serum