Cobra Venom Factor - Recombinant

Uniform pool of recombinant Cobra Venom Factor (CVF), a non-toxic complement activating reagent.


Product Specifications

Citations 0
Description

Uniform pool of recombinant Cobra Venom Factor (CVF), a non-toxic complement activating reagent.

Storage Store at -70°C or below. Minimize freeze/thaw cycles.
Form

Frozen liquid (Phosphate Buffered Saline, pH 7.2 ± 0.2)

Concentration 100 μg/mL
Applications

See citations and technical data sheet for application info.

Ordering Information

For Research Use Only. Not for use in diagnostic procedures.
Catalog Number A601
Catalog Number (CE) N/A
Size 0.5 mL
Price (USD) $535.00
Price (EURO) 535,00 €

Contact us

US Phone+1 (858) 552 1100
EU Phone+353 (91) 412 474
US Emailcontact-us@quidelortho.com
EU Emailcontact-emea@quidelortho.com

Specifications

Description

Uniform pool of recombinant Cobra Venom Factor (CVF), a non-toxic complement activating reagent.

Size 0.5 mL
Storage

Store at -70°C or below. Minimize freeze/thaw cycles.

Form Frozen liquid (Phosphate Buffered Saline, pH 7.2 ± 0.2)
Concentration 100 μg/mL
Applications See citations and technical data sheet for application info.
Purity ≥ 95% by SDS page
Source

Refer to certificate of analysis

Activity ≥ 350 units
Molecular Weight N/A
Background

Cobra Venom Factor (CVF), sometimes referred to as C3b(Cobra), is the non-toxic, complement activating component of cobra venom. Like naturally occurring C3b, CVF forms a complex with complement components Factor B and Factor D. This CVFBbD convertase is capable of activating C3 in a wide variety of species via the alternative complement pathway. Unlike the naturally occurring convertase (C3bBbD), the C3b(Cobra)BbD convertase is Factor H resistant and is therefore not inactivated by Factor I or CR1. Given appropriate incubation time, CVF will convert nearly 100% of the C3 to C3 end products. Unlike CVF purified from the Naja naja haje species, CVF from Naja naja kaouthia activates the terminal pathway directly by forming a C5 convertase. This depletes C5 in a manner analogous to that described above for C3. Levels of iC3b, C3a, SC5b-9, C5a and the Factor B cleavage product Bb are all extremely high in CVF treated sera.

Citations

Title Year Applications Sample Species Sample Sample Details