C7 Antibody (Monoclonal)
A murine monoclonal antibody to an epitope on C7 protein.
Product Specifications
| Citations | 4 |
|---|---|
| Clonality |
Monoclonal |
| Immnogen | |
| Applications | See citations and technical data sheet for application info. |
| Concentration | 1.0-1.2 mg/mL |
| Conjugate | Unconjugated |
| Cross Reactivity |
Human, Bovine, Cat, Dog, Hamster, Horse, Rabbit, Rat. |
Ordering Information
| Catalog Number | A221 |
|---|---|
| Catalog Number (CE) | N/A |
| Size | 100 µl |
| Price (USD) | $365.00 |
| Price (EURO) | 330,00 € |
Contact us
| US Phone | +1 (858) 552 1100 |
|---|---|
| EU Phone | +353 (91) 412 474 |
| US Email | contact-us@quidelortho.com |
| EU Email | contact-emea@quidelortho.com |
- Specifications
- Citations
- Certificate of Analysis
Specifications
| Description |
A murine monoclonal antibody to an epitope on C7 protein. |
|---|---|
| Size | 100 µl |
| Concentration |
1.0-1.2 mg/mL |
| Applications | See citations and technical data sheet for application info. |
| Form | Liquid. Borate Buffered Saline (pH 8.4 ± 0.2), with ≤ 0.1% Sodium Azide. |
| Clonality | Monoclonal |
| Immunogen | Purified human protein. |
| Conjugate | Unconjugated |
| Cross Reactivity | Human, Bovine, Cat, Dog, Hamster, Horse, Rabbit, Rat. |
| Isotype | IgG1k |
| Purity | ≥ 95% by SDS PAGE |
| Source |
Mouse |
| Specificity | This monoclonal antibody was raised against purified human C7. It is specific for an Antigen expressed on native C7 but not expressed in MAC. It will inhibit the lysis of EA and will not detect membrane bound MAC. |
| Storage |
Short term (30 days) 4˚C. Long term at or below –20˚C. |
| Background |
Complement component C7 is a single-chain glycoprotein with a molecular weight of 95 kD. C7 protein is present in human plasma at an approximate concentration of 55 μg/ml. Upon activation of the lectin, classical or alternative pathways, C7 becomes integrated into the terminal complement complex. The Terminal Complement Complex (TCC) is a general term for both membrane-bound C5b-9, or Membrane Attack Complex (MAC), and fluid phase SC5b-9. TCC is an excellent marker for quantifying the extent of terminal pathway activation in vivo or in vitro. TCC can be deposited on the surface of transformed cells, biomaterials, as well as, a variety of other materials. |
Citations
| Title | Year | Applications | Sample Species | Sample | Sample Details |
|---|---|---|---|---|---|
| 2015 | Opsonophagocytic killing assay |
Bacteria |
Neisseria meningitidis |
||
|
Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release. |
2014 | Phagocytosis assay |
Human |
Whole Blood |
|
| 2017 | Serum Bactericidal Assay |
Human |
Serum |
Neisseria meningitidis |
|
| 2008 | FC, IF |
Rat |
Spinal Cord Tissue |
Certificate of Analysis
