C4 Protein

Purified human C4 protein

Product Specifications

Citations 6
Description

Purified human C4 protein
Storage Store at -70°C or below. Avoid freeze/thaw.
Form

Frozen liquid. 10 mM sodium phosphate, 145 mM NaCl, pH 7.3. No preservative, 0.22 µm filtered.
Concentration 1.0 mg/mL (refer to CoA for lot specific concentration)
Applications

See citations and technical data sheet for application info.
Technical Documents

Ordering Information

For Research Use Only. Not for use in diagnostic procedures.
Catalog Number A402
Catalog Number (CE) N/A
Size 250 µL
Price (USD) $325.00
Price (EURO) 290,00 €
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EU Phone+353 (91) 412 474
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Specifications

Description

Purified human C4 protein
Size 250 µL
Storage

Store at -70°C or below. Avoid freeze/thaw.

Form Frozen liquid. 10 mM sodium phosphate, 145 mM NaCl, pH 7.3. No preservative, 0.22 µm filtered.
Concentration 1.0 mg/mL (refer to CoA for lot specific concentration)
Applications See citations and technical data sheet for application info.
Purity >90% by SDS-PAGE
Source

Normal human serum
Activity >80% versus normal human serum standard
Molecular Weight 205,000 Da (3 chains)
Background

Purified human complement component C4. C4 is one of the proteins unique to the Classical Complement Pathway. The 200 kD C4 protein is made up of three peptide chains linked by disulfide bonds and contains a thioesterbond. When the classical pathway is activated, C1s cleaves C4 to C4a (a weak anaphylatoxin) and C4b. C4b can then bind covalently to a target surface or complex. It can then function as an opsonin or participate as part classical pathway convertase. C4 has been shown to exist as two separate "complotypes" C4A and C4B. These have been shown to have different biological properties.

Certificate of Analysis

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